We are seeking an experienced and highly skilled Molecular Genetics Clinical Laboratory Director – Oncology or Senior Laboratory Director – Oncology to provide technical leadership and oversee the daily operations of our high-complexity oncology clinical laboratory. The Oncology Laboratory Director is responsible for ensuring accurate interpretation and reporting of oncology test results, maintaining regulatory compliance, driving quality improvements, and collaborating cross-functionally to advance our oncology assays. This is a full-time, onsite role (2-3 days/week) in Menlo Park, CA.

Responsibilities:

• Provide technical oversight to ensure high-quality oncology testing and alignment with laboratory and clinical goals.
• Interpret somatic variant results from Northstar liquid biopsy assays, classify variants, and sign out oncology clinical reports.
• Troubleshoot technical issues related to oncology workflows, including liquid biopsy sample prep, NGS library preparation, sequencing, and data analysis.
• Evaluate lab performance, implement process improvements, and promote robust quality assurance systems.
• Review Non-Conforming Events and CAPAs to ensure timely resolution of issues impacting oncology test performance.
• Ensure compliance with CLIA, CAP, NYSDOH, and other applicable regulatory standards for oncology assays.
• Oversee accurate documentation of SOPs, validation reports, QC records, personnel competencies, proficiency testing, and report archives.
• Collaborate with bioinformatics, R&D, and medical affairs on assay development, interpretation guidelines, and continuous assay optimization.
• Participate in budget planning and manage lab expenses to ensure financial efficiency while maintaining exceptional quality.
• Support special projects, including scaling new oncology tests, preparing for inspections, and implementing automation.
• Serve as a subject matter expert on oncology variant interpretation, including AMP/CAP/NYS guidelines.

Qualifications:

• Doctoral degree (PhD, MD, or equivalent) in genetics, molecular biology, or a related field.
• Board certification (ABMGG, ABP in Molecular Genetic Pathology, or equivalent).
• Valid or eligible for California Clinical Laboratory Director license (CGMB, CGMBS, MD/DO licensure) and New York State CoQ in oncology testing.
• 4+ years in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH), with at least 3 years in molecular oncology testing including NGS.
• Proven leadership in developing, validating, and implementing oncology assays (e.g., somatic mutation panels, methylation assays).
• Deep knowledge of cancer genomics, including tumor heterogeneity, somatic driver mutations, and targeted therapies.
• Experience with variant interpretation databases (COSMIC, OncoKB, ClinVar), IGV, BAM file review, and molecular tumor board participation.
• Strong analytical, communication, and organizational skills, with a track record of leading teams in high-growth environments.
• Proficiency with LIMS and oncology-focused bioinformatics tools.

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of up to $466,802 per year, including a base pay range of $216,481 - $264,002per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.