Twist Bioscience is seeking a highly motivated and enthusiastic Manager, Antibody Characterization to join our dynamic Operations Team. This is an exciting opportunity to lead a critical function within a fast-paced, high-growth synthetic biology environment. The ideal candidate will thrive on the challenge of building new product lines while enforcing the rigor and accountability essential for delivering world-class, high-quality products to both internal and external customers.
Onsite - 5 Days per week - Wilsonville, Oregon.
What You’ll Be Doing:
- Manage, train, and mentor production team members, fostering a collaborative and high-performing laboratory environment.
- Overseeing, running, and troubleshooting antibody characterization experiments using advanced analytical techniques (e.g. BLI and SPR) in a variety of formats to evaluate binding kinetics, ligand blocking, and binning.
- Act as the primary point of contact for shift Manufacturing Associates and Specialists, ensuring the team adheres to the plan of record.
- Provide guidance, oversee priority decisions, and lead troubleshooting efforts for production issues as they arise.
- Establish and track Key Performance Indicators (KPIs) to drive production efficiency and meet department goals.
- Model capacity and recommend high-throughput workflow options and staffing plans based on demand forecasts.
- Drive operational excellence by identifying and implementing Continuous Process Improvement (CPI) initiatives to increase capacity, reduce Turnaround Time (TAT), and lower Cost of Goods Sold (COGS).
- Lead complex technical investigations and risk assessments related to processes, including resolving customer incidents.
- Maintain thorough, accurate, and detailed documentation of all work in batch records, databases, or other approved formats, including problems and deviations.
- Develop and revise Standard Operating Procedures (SOPs), work instructions, and training documents for the characterization of proteins/antibodies.
- Ensure the team operates in compliance with necessary quality standards.
- Collaborate with internal and external customers on protein production projects
- Work closely with the Director and support functions to evaluate opportunities for product line improvements, contributing to Twist's strategic vision.
- Lead cross-functional projects, including running recurring status meetings and managing assignments across teams in the US, Europe, and Asia.
What You'll Bring to the Team
- B.S. or M.S. degree in Biology, Biochemistry, Immunology, Process Engineering, or a related field.
- 5+ years of experience in the biotech/pharmaceutical industry, preferably involving the characterization of diagnostic and/or therapeutic antibodies.
- Strong understanding of antibody discovery, preferably focusing on assay development and protein characterization
- Previous experience with BLI, SPR, and ELISA strongly preferred.
- A proven track record of successfully developing and manufacturing protein-based commercial products.
- Demonstrated scientific leadership, mentoring, and organizational skills in managing direct reports and overseeing external collaborations (e.g., CROs).
- Deep expertise in basic synthetic/molecular biology skills, including Mammalian Cell Culturing, Transfection, Buffer Exchange, and molecular biology workflows.
- Excellent project management skills: proficient with timeline development, project tracking, and the ability to efficiently manage and prioritize multiple projects.
- Exceptional attention to detail, organizational, and record-keeping skills.
- Familiarity with PLM, ERP, and MES management systems is a plus.
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