The Opportunity

insitro is a physical AI company dedicated to unlocking causal human biology and accelerating the delivery of better medicines to patients. Our unique Virtual Human™ platform identifies novel, high-impact genetic intervention points, which our TherML™ platform translates into therapeutics—whether small molecules, biologics, or oligos. With multiple programs in metabolic disease and neuroscience advancing toward the clinic, and our first IND submission slated for the second half of this year, we are at a pivotal inflection point.

This role adds senior in-house legal capacity to protect insitro's science and pipeline. Reporting to the VP, Head of Intellectual Property, you will lead patent preparation, prosecution, and freedom-to-operate analyses across therapeutic programs and the machine-learning platform. You will also help design and implement IP strategy that keeps pace with the legal developments shaping AI-native pharmaceutical companies—translating shifts in the law quickly into filings that strengthen insitro's scientific, competitive, and IP position. Based in South San Francisco, this is a hybrid role with three days onsite and two days remote.

Responsibilities

Patent Preparation & Prosecution

• Draft and Prosecute: Prepare and prosecute U.S. and foreign patent applications across the therapeutic pipeline and machine-learning platform

• Ownership & Assignment: Manage inventorship, ownership, and assignment matters across jurisdictions

IP Strategy & Portfolio Management

• Shape the Strategy: Help design, implement, and evolve IP strategy and asset lifecycle management in step with the rapidly shifting legal landscape for AI-native pharma

• Competitive Intelligence: Monitor patent filings, publications, and pipeline developments of competitors and translate complex landscape data into strategic recommendations for corporate strategy and business development

• Trademark & Trade Secret: Manage the trademark portfolio and support trade-secret strategy and protection

Risk & Transactions

• FTO & Counseling: Conduct and lead freedom-to-operate, patentability, validity, and infringement analyses, and counsel scientific and business colleagues on data-use agreements and use of open-source software, AI models, and third-party datasets

• Due Diligence: Support IP due diligence for partnerships, collaborations, and financing transactions

Invention Capture & Operations

• Embed with R&D: Identify and protect patentable innovations by partnering with research teams to establish systematic invention capture workflows and reviewing upcoming publications to prevent premature disclosure

• Outside Counsel & Budget: Manage outside counsel, foreign associates, and the IP budget; prepare IP strategy and portfolio reviews for leadership

• Docket Discipline: Maintain docket and information-disclosure-statement (IDS) discipline in partnership with the IP paralegal

About You

Experience & Qualifications

• Legal Credentials: J.D., active state bar membership, and USPTO registration (patent bar); this is an attorney role

• Scientific Foundation: Ph.D. in a life-science field

• Prosecution Depth: 8-10+ years as a patent attorney with substantial pharmaceutical/biopharma patent preparation and prosecution experience (in-house or firm), including written-description and enablement strategy

• Both Sides of the Table: Experience on the innovator side (offensive claiming and moat-building) and the fast-follower side (FTO analysis and navigation, licensing, and secondary patents)

• Full IP Toolkit: Breadth across patents, trademarks, trade secrets, and copyright, with exposure to handling IP in partnerships, licensing, and business transactions being a plus

• Subject Matter Expertise: Deep expertise in nucleic-acid and/or antibody therapeutics and working knowledge of AI/ML methods and their application in drug discovery are both pluses

• Technical Skills: Comfort using— or eagerness to learn — AI tools and workflows

Core Competencies

• Strategic Translator: You convert shifts in patent law and the competitive landscape into concrete filing decisions that move fast enough to matter

• Embedded Partner: You build trust with scientists and engineers, making invention capture feel like a natural part of how R&D works rather than a legal obligation

• Operational Owner: You run a tight ship — docket, budget, outside counsel, and IDS discipline — without losing sight of the bigger strategic picture

Compensation & Benefits at insitro

Our target starting salary for successful US-based applicants for this role is $255,000 - $312,000. To determine starting pay, we consider multiple job-related factors including a candidate's skills, education and experience, market demand, business needs, and internal parity. We may also adjust this range in the future based on market data.

This role is eligible for participation in our Annual Performance Bonus Plan (based on company targets by role level and annual company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies.

In addition, insitro also provides our employees:

• 401(k) plan with employer matching for contributions

• Excellent medical, dental, and vision coverage as well as mental health and well-being support

• Open, flexible vacation policy

• Paid parental leave of at least 16 weeks to support parents who give birth, and 10 weeks for a new parent (inclusive of birth, adoption, fostering, etc)

• Quarterly budget for books and online courses for self-development

• New hire stipend for home office setup

• Monthly cell phone & internet stipend

• Access to free onsite baristas and daily lunch for employees who are either onsite or hybrid

• Access to a free commuter bus network that provides transport to and from our South San Francisco HQ from locations all around the Bay Area

insitro is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.

Please be aware of recruitment scams: we never request payments, all recruitment communications are from @insitro.com, and if in doubt, contact us at [email protected].

#LI-Hybrid

About insitro

insitro is a drug discovery and development company using machine learning (ML) and data at scale to decode biology for transformative medicines. At the core of insitro’s approach is the convergence of in-house generated multi-modal cellular data and high-content phenotypic human cohort data. We rely on these data to develop ML-driven, predictive disease models that uncover underlying biologic state and elucidate critical drivers of disease. These powerful models rely on extensive biological and computational infrastructure and allow insitro to advance novel targets and patient biomarkers, design therapeutics and inform clinical strategy. insitro is advancing a wholly owned and partnered pipeline of insights and therapeutics in neuroscience and metabolism. Since launching in 2018, insitro has raised over $700 million from top tech, biotech and crossover investors, and from collaborations with pharmaceutical partners. For more information on insitro, please visit www.insitro.com.