Location: This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

Praxis is looking for a talented and experienced leader for a key program expected to advance best in class or first-in-class products for areas of high unmet medical need. The ideal candidate is a strong, multi-faceted leader who thrives in environments with high ambiguity, limited hierarchy, and real ownership of outcomes as the program continues its rapid trajectory of transformational patient impact.

This results-oriented individual will be characterized by a strong strategic mind, a collaborative nature and intellectual curiosity, and will credibly and enthusiastically work across the spectrum of research, development, technical operations, and commercialization. They will lead a cross-functional program team and be responsible and accountable for Praxis’ program strategy, driving decision-making, and ensuring efficient and high-quality execution.

Praxis is committed to a high-energy, fast-pace and flat organization where individuals work as peers with singular objective to bring drugs to patients. This role is not about coordinating consensus; it is about building alignment, deeply understanding all aspects of the development activities for the product and driving the program forward. The Program Lead must embrace and exemplify this way of working.

Primary Responsibilities

• Internally and externally communicate a shared and bold vision for the program.
• Lead, manage, and maintain the Program Team, partnering with functional leads to ensure team effectiveness and operational excellence while retaining clear accountability for program-level decisions.
• Lead the creation and execution of the program strategy and integrated development plan(s).
• In collaboration with the Program Team, define and deliver against program OKRs.
• Provide strategic oversight for program budgets and resourcing, actively shaping—not just tracking—investment decisions.
• Architect scenarios to inform decision making and program planning; ensure that the right skills and capabilities exist on the team to effectively execute on the program plan.
• Be a role model for Praxons: inspire ambitious goals, give and receive direct feedback, and build trust through transparency and follow-through.
• “Roll up sleeves and get hands dirty” for the benefit of the team and the program; wear multiple hats, step into gaps, and hold yourself to the same standards as the team.
• Serve as the primary integration point with corporate processes without creating unnecessary bureaucracy.

Qualifications and Key Success Factors

• Demonstrated drug development experience with a strong track record of cross-functional leadership; experience across the full development lifecycle strongly preferred
• Strong holistic understanding of the drug development process across functions
• Ability to translate strategy into execution, driving decisions that create value under real-world constraints
• Clear, compelling communicator across internal and external stakeholders

What Sets Successful Praxons Apart

• Comfort operating with limited hierarchy and high personal accountability
• Learning agility and intellectual curiosity; ability to rapidly develop deep understanding of new therapeutic areas
• Willingness to challenge assumptions, surface risks early, and engage in healthy debate in service of the best outcome
• Demonstrated ability to balance urgency with rigor in fast-moving environments

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. Final salary range may be modified commensurate with job level, education, and experience.